AB0811 NAILFOLD CAPILLAROSCOPY FINDINGS IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES AND ITS ASSOCIATION TO AUTOANTIBODIES: A CASE-CONTROL STUDY

Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of acquired muscle diseases, which have distinct clinical, pathological and histological features. Autoantibodies clinically useful biomarkers to help the diagnosis IIM. Raynaud’s phenomenon is very frequent presence microvascular changes in IIM been described however, role nailfold videocapillaroscopy NVC) for prognosis not clearly established. Objectives The aim this study was relationship between clinical immunological characteristics (NVC) abnormalities patients with idiopathic (IIMs). Methods We performed retrospective followed University Hospital. Patients underwent NVC at 200x magnification. Epidemiological, data antibody status, including myositis scleroderma panel all retrieved. findings loss capillary density, enlarged giant capillaries, ramified haemorrhages, thrombosis, avascular areas, disorganization architecture subpapillary venous plexus were recollected, if present. For comparison qualitative and/or quantitative variables Fisher’s exact Test or T-test when necessary. Results 95 during follow-up included (66% female) median age inclusion 55.3±24 years. Median duration 6.8±7 39% had first evaluation 58% them showed findings. Table 1 Summarizes epidemiological, autoantibody status patients. found an association dysphagia areas (p=0.02) abnormal organization (p<0.01) on NVC. ILD associated (p=0.04) (p=0.004). Anti-MDA5+ (p=0.03), thrombosis capillaries (p=0.04). Anti-Mi2+ anti-Th/To (p=0.017 p=0.001). haemorrhages anti-Ku+ (p=0.048) anti-PL12+ (p=0.046). anti-RNA-pol III anti-NXP2 (p=0.044). A significant anti-Ro52 (OR 2.69, CI 95% 1.05-6.8, p 0.03) anti-Jo1 7.03 1.46-33.7, 0.01) found. Anti-PML 4.32 1.35-10.42, 0.038) 5.82 1.89-13.24, 0.04) dysphagia. Anti-MDA5 5.85 1.92-14.21, 0.044) skin involvement. Conclusion certain autoantibodies related degree microangiopathy associates capillaroscopic changes. Studying diagnostic pathogenic can provide information regarding current knowledge about pathogenesis, classification, disease. : NFC features from Clinical Muscle weakness 79 (83%) Skin 30 (32%) 47 (49%) Dysphagia 18 (19%) 37 (39%) CK elevation 45 (47%) Cardiac disease 4 (4%) Loss density 27 (28%) Enlarged Haemorrhages 36 (38%) Thrombosis 19 (20%) Avascular 26 (27%) Disorganization 24 (25%) Subpapillary Antibody Disease-specific antibodies 8 (8%) Anti-TIF1G 11 (12%) Anti-MI2 Anti-NXP2 6 (6%) Anti-synthetase Anti-Jo1 13 (14%) Anti-PL7 9 (9%) Anti-PL12 5 (5%) Disease-associated Anti-Ro52 Anti-KU Antinuclear Others (EJ, SRP, PM-SCL75, PM-SCL100, CN1A ) 61 (64%) 22 (23%) REFERENCES: NIL. Acknowledgements: Disclosure Interests None Declared.